Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kashin-Beck disease
Journal of Zhejiang University: Science B, ISSN: 1673-1581, Vol: 11, Issue: 3, Page: 200-208
2010
- 27Citations
- 23Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations27
- Citation Indexes27
- 27
- CrossRef19
- Captures23
- Readers23
- 23
Article Description
Objective: To investigate the effects of mycotoxin moniliformin (MON) on the metabolism of aggrecan and type II collagen in human chondrocytes in vitro and the relationship between MON and Kashin-Beck disease (KBD). Methods: Human chondrocytes were isolated and cultured on bone matrix gelatin to form an artificial cartilage model in vitro with or without MON toxin. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The expression of aggrecan and type II collagen in the cartilage was determined using immunocytochemical staining. Results: MON toxin inhibited chondrocyte viability in dose-dependent and time-dependent manners. MON reduced aggrecan and type II collagen syntheses in the tissue-engineered cartilage. MON also increased the expression of matrix metalloproteinase-1 (MMP-1), MMP-13, BC4 epitopes, and CD44 in cartilages. However, the expression of 3B3(-) epitopes in cartilages was inhibited by MON. Selenium partially alleviated the damage of aggrecan induced by MON toxin. Conclusion: MON toxin promoted the catabolism of aggrecan and type II collagen in human chondrocytes. © 2010 Zhejiang University and Springer Berlin Heidelberg.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77951116780&origin=inward; http://dx.doi.org/10.1631/jzus.b0900074; http://www.ncbi.nlm.nih.gov/pubmed/20205306; http://link.springer.com/10.1631/jzus.B0900074; http://www.springerlink.com/index/10.1631/jzus.B0900074; http://www.springerlink.com/index/pdf/10.1631/jzus.B0900074; https://link.springer.com/article/10.1631%2Fjzus.B0900074; http://sciencechina.cn/gw.jsp?action=cited_outline.jsp&type=1&id=3859523&internal_id=3859523&from=elsevier; https://dx.doi.org/10.1631/jzus.b0900074; https://link.springer.com/article/10.1631/jzus.B0900074; http://link.springer.com/article/10.1631%2Fjzus.B0900074; https://link.springer.com/content/pdf/10.1631%2Fjzus.B0900074.pdf
Zhejiang University Press
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