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Got calcium? Welcome to the calcium-alkali syndrome

Journal of the American Society of Nephrology, ISSN: 1533-3450, Vol: 21, Issue: 9, Page: 1440-1443
2010
  • 78
    Citations
  • 0
    Usage
  • 87
    Captures
  • 1
    Mentions
  • 6
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    78
  • Captures
    87
  • Mentions
    1
    • References
      1
      • Wikipedia
        1
  • Social Media
    6
    • Shares, Likes & Comments
      6
      • Facebook
        6

Article Description

We recommend changing the name of the milk-alkali syndrome to the calciumalkali syndrome, because the new terminology better reflects the shifting epidemiology and understanding of this disorder. The calcium-alkali syndrome is now the third most common cause of hospital admission for hypercalcemia, and those at greatest risk are postmenopausal or pregnant women. The incidence of the calcium-alkali syndrome is growing in large part as a result of the widespread use of over-the-counter calcium and vitamin D supplements. Advertising for treatment or prevention of osteoporosis has long encouraged this use. Intricate mechanisms mediating the calcium-alkali syndrome depend on interplay among intestine, kidney, and bone. New insights regarding its pathogenesis focus on the key role of calcium-sensing receptors and TRPV5 channels in the modulation of renal calcium excretion. Restoring extracellular blood volume, increasing GFR and calcium excretion, and discontinuing calcium supplementation provide best treatment. Copyright © 2010 by the American Society of Nephrology.

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