αENaC-mediated lithium absorption promotes nephrogenic diabetes insipidus
Journal of the American Society of Nephrology, ISSN: 1533-3450, Vol: 22, Issue: 2, Page: 253-261
2011
- 78Citations
- 44Captures
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Metrics Details
- Citations78
- Citation Indexes78
- 78
- CrossRef65
- Captures44
- Readers44
- 44
Article Description
Lithium-induced nephrogenic diabetes insipidus (NDI) is accompanied by polyuria, downregulation of aquaporin 2 (AQP2), and cellular remodeling of the collecting duct (CD). The amiloride-sensitive epithelial sodium channel (ENaC) is a likely candidate for lithium entry. Here, we subjected transgenic mice lacking αENaC specifically in the CD (knockout [KO] mice) and littermate controls to chronic lithium treatment. In contrast to control mice, KO mice did not markedly increase their water intake. Furthermore, KO mice did not demonstrate the polyuria and reduction in urine osmolality induced by lithium treatment in the control mice. Lithium treatment reduced AQP2 protein levels in the cortex/outer medulla and inner medulla (IM) of control mice but only partially reduced AQP2 levels in the IM of KO mice. Furthermore, lithium induced expression of H-ATPase in the IM of control mice but not KO mice. In conclusion, the absence of functional ENaC in the CD protects mice from lithium-induced NDI. These data support the hypothesis that ENaC-mediated lithium entry into the CD principal cells contributes to the pathogenesis of lithium-induced NDI. Copyright © 2011 by the American Society of Nephrology.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79551655247&origin=inward; http://dx.doi.org/10.1681/asn.2010070734; http://www.ncbi.nlm.nih.gov/pubmed/21051735; http://www.jasn.org/cgi/doi/10.1681/ASN.2010070734; https://syndication.highwire.org/content/doi/10.1681/ASN.2010070734; https://journals.lww.com/00001751-201102000-00012; https://facultyopinions.com/prime/8986956#eval9549054; http://dx.doi.org/10.3410/f.8986956.9549054; https://facultyopinions.com/prime/8986956#eval10871055; http://dx.doi.org/10.3410/f.8986956.10871055; https://www.zora.uzh.ch/id/eprint/42522; https://dx.doi.org/10.1681/asn.2010070734; https://journals.lww.com/jasn/Fulltext/2011/02000/_ENaC_Mediated_Lithium_Absorption_Promotes.12.aspx; http://dx.doi.org/10.5167/uzh-42522; https://dx.doi.org/10.5167/uzh-42522; https://www.zora.uzh.ch/id/eprint/42522/; http://f1000.com/8986956#eval10871055; http://f1000.com/8986956#eval9549054; http://www.jasn.org/lookup/doi/10.1681/ASN.2010070734; https://jasn.asnjournals.org/content/22/2/253; https://jasn.asnjournals.org/content/22/2/253.abstract; https://jasn.asnjournals.org/content/jnephrol/22/2/253.full.pdf; https://www.zora.uzh.ch/id/eprint/42522/1/2010_Christensen-et-al.pdf; http://jasn.asnjournals.org/content/22/2/253; https://jasn.asnjournals.org/content/22/2/253.full.pdf
American Society of Nephrology (ASN)
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