Aproximación diagnóstica de los errores innatos del metabolismo en la unidad de cuidado intensivo neonatal: acidosis metabólica, hiperamonemia e hipoglicemia
Biosalud, ISSN: 1657-9550, Vol: 16, Issue: 2, Page: 83-95
2017
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Article Description
RESUMEN Los errores innatos del metabolismo del neonato son enfermedades que requieren una intervención temprana, dado que el manejo oportuno permite la prevención de secuelas severas o desenlaces fatales. Sin embargo, su diagnóstico se dificulta debido a las múltiples manifestaciones clínicas inespecíficas que lo acompañan y a las diversas alteraciones metabólicas que afectan la lectura de los estudios paraclínicos de rutina; sin embargo, una aproximación sistemática que tenga en cuenta las variaciones del metabolismo intermedio, interpretadas a través de pruebas básicas de laboratorio, permite alcanzar en la mayoría de los casos, un diagnóstico certero. La aproximación aquí propuesta se basa en la interpretación de tres estados metabólicos: acidosis metabólica, hiperamonemia e hipoglicemia, y su relación con los resultados de tests de laboratorio que están a la mano en la mayoría de unidades de neonatología. Se plantean diversas recomendaciones en relación a valores normales, flujogramas diagnósticos y recomendaciones sobre toma y conservación de muestras.
Bibliographic Details
https://revistasojs.ucaldas.edu.co/index.php/biosalud/article/view/3714; http://dx.doi.org/10.17151/biosa.2017.16.2.8; http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1657-95502017000200083&lng=en&tlng=en; http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S1657-95502017000200083&lng=en&tlng=en; http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S1657-95502017000200083; http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S1657-95502017000200083; https://dx.doi.org/10.17151/biosa.2017.16.2.8
Universidad de Caldas
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