The luminescent Chalcones. Its potential use as a luminescent and antitumoral agents
Vitae, ISSN: 2145-2660, Vol: 29, Issue: 3
2022
- 1Citations
- 8Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Background: Hepatocellular carcinoma (HCC) is one of the most diagnosed cancers worldwide. Chemoprevention of HCC can be achieved using natural or synthetic compounds that reverse, suppress, detect, or prevent cancer progression. Objectives: In this study, both the antiproliferative effects and luminescent properties of 2’-hydroxychalcones were evaluated. Methods: Cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay, spectroscopy assays, and density functional theory (DFT) calculations were used to determine the luminescent properties of 2´-hydroxychalcones. Results: Cytotoxic effects of 2´-hydroxychalcones were observed over the HepG2 and EA.hy926 cells. Since the chalcone moiety could be used as a fluorescent probe, these compounds may be helpful in cancer diagnosis and tumor localization. They may enable tumor observation and regression through the fluorescence during treatment; therefore, the compounds are a potential candidate as novel anticancer agents acting on human hepatomas. Conclusions: This report describes the chalcones’ use as a specific luminescent biomarker in tumor cells. We also report the cellular uptake of 2’-hydroxychalcones, their cellular distribution, and the mechanisms that may be responsible for their cytotoxic effects.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85137343348&origin=inward; http://dx.doi.org/10.17533/udea.vitae.v29n3a347295; https://revistas.udea.edu.co/index.php/vitae/article/view/347295; http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042022000300001&lng=en&tlng=en; http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0121-40042022000300001&lng=en&tlng=en; http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042022000300001; http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0121-40042022000300001; https://dx.doi.org/10.17533/udea.vitae.v29n3a347295
Universidad de Antioquia
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