The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain
Oncotarget, ISSN: 1949-2553, Vol: 7, Issue: 19, Page: 26949-26965
2016
- 19Citations
- 17Captures
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Metrics Details
- Citations19
- Citation Indexes19
- 19
- CrossRef17
- Captures17
- Readers17
- 17
Article Description
Although there were considerable advances in the anti-aging medical field, it is short of therapeutic drug for anti-aging. Mounting evidence indicates that the immunosenescence is the key physiopathological mechanism of aging. This study showed the treatment of LW-AFC, an herbal medicine, decreased the grading score of senescence, increased weight, prolonged average life span and ameliorated spatial memory impairment in 12-and 24-month-old senescence accelerated mouse resistant 1 (SAMR1) strain. And these anti-aging effects of LW-AFC were more excellent than melatonin. The administration of LW-AFC enhanced ConA-and LPS-induced splenocyte proliferation in aged SAMR1 mice. The treatment of LW-AFC not only reversed the decreased the proportions of helper T cells, suppressor T cells and B cells, the increased regulatory T cells in the peripheral blood of old SAMR1 mice, but also could modulate the abnormal secretion of IL-1β, IL-2, IL-6, IL-17, IL-23, GM-CSF, IFN-γ, TNF-α, TNF-β, RANTES, eotaxin, MCP-1, IL-4, IL-5, IL-10 and G-CSF. These data indicated that LW-AFC reversed the immunosenescence status by restoring immunodeficiency and decreasing chronic inflammation and suggested LW-AFC may be an effective anti-aging agent.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84968735875&origin=inward; http://dx.doi.org/10.18632/oncotarget.8877; http://www.ncbi.nlm.nih.gov/pubmed/27105505; https://www.oncotarget.com/lookup/doi/10.18632/oncotarget.8877; https://dx.doi.org/10.18632/oncotarget.8877; https://www.oncotarget.com/article/8877/text/
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