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Responses of molecular indicators of exposure in mesocosms: Common carp (Cyprinus carpio) exposed to the herbicides alachlor and atrazine

Environmental Toxicology and Chemistry, ISSN: 0730-7268, Vol: 24, Issue: 1, Page: 190-197
2005
  • 37
    Citations
  • 0
    Usage
  • 36
    Captures
  • 0
    Mentions
  • 603
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    37
  • Captures
    36
  • Social Media
    603
    • Shares, Likes & Comments
      603
      • Facebook
        603

Article Description

Common carp (Cyprinus carpio) were treated in aquatic mesocosms with a single pulse of the herbicides atrazine or alachlor to study the bioavailability and biological activity of these herbicides using molecular indicators: Liver vitellogenin gene expression in male fish for estrogenic activity, liver cytochrome P4501A1 gene expression, and DNA damage in blood cells using the single-cell gel electrophoresis method. Both alachlor and atrazine showed dose-related increases in DNA strand breaks at environmentally relevant concentrations (<100 ppb). Gene expression indicators showed that neither herbicide had estrogenic activity in the carp, whereas atrazine at concentrations as low as 7 ppb induced cytochrome P4501A1. These results support the study of molecular indicators for exposure in surrogate ecosystems to gauge relevant environmental changes following herbicide treatments.

Bibliographic Details

Lina W. Chang; Gregory P. Toth; Denise A. Gordon; David W. Graham; John R. Meier; Charles W. Knapp; F. Jerry deNoyelles Jr.; Scott Campbell; David L. Lattier

Oxford University Press (OUP)

Environmental Science

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