Therapeutic Bacteriophages for Gram-Negative Bacterial Infections in Animals and Humans
Pathogens and Immunity, ISSN: 2469-2964, Vol: 7, Issue: 2, Page: 1-45
2022
- 18Citations
- 45Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations18
- Citation Indexes18
- 18
- Captures45
- Readers45
- 45
- Mentions1
- News Mentions1
- 1
Most Recent News
Transplantation-Oncology Infectious Diseases Program Researchers Provide Details of New Studies and Findings in the Area of Gram-Negative Bacterial Infections (Therapeutic Bacteriophages for Gram-Negative Bacterial Infections in Animals and ...)
2022 NOV 01 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Research findings on gram-negative bacterial infections are discussed in
Review Description
Drug-resistant Gram-negative bacterial pathogens are an increasingly serious health threat causing worldwide nosocomial infections with high morbidity and mortality. Of these, the most prevalent and severe are Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Salmonella typhimurium. The extended use of antibiotics has led to the emergence of multidrug resistance in these bacteria. Drug-inactivating enzymes produced by these bacteria, as well as other resistance mechanisms, render drugs ineffective and make treatment of such infections more difficult and complicated. This makes the development of novel antimicrobial agents an urgent necessity. Bacteriophages, which are bacteria-killing viruses first discovered in 1915, have been used as therapeutic antimicrobials in the past, but their use was abandoned due to the widespread availability of antibiotics in the 20th century. The emergence, however, of drug-resistant pathogens has re-affirmed the need for bacteriophages as therapeutic strategies. This review describes the use of bacteriophages as novel agents to combat this rapidly emerging public health crisis by comprehensively enumerating and discussing the innovative use of bacteriophages in both animal models and in patients infected by Gram-negative bacteria.
Bibliographic Details
Case Western Reserve University
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