Medical applications of leukocyte surface molecules - The CD molecules
Molecular Medicine, ISSN: 1076-1551, Vol: 12, Issue: 11-12, Page: 312-316
2006
- 32Citations
- 33Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations32
- Citation Indexes32
- 32
- CrossRef1
- Captures33
- Readers33
- 33
Conference Paper Description
Leukocytes are the cells of the immune system and are centrally involved in defense against infection, in autoimmune disease, allergy, inflammation, and in organ graft rejection. Lymphomas and leukemias are malignancies of leukocytes, and the immune system is almost certainly involved in most other cancers. Each leukocyte expresses a selection of cell surface glycoproteins and glycolipids which mediate its interaction with antigen, with other components of the immune system, and with other tissues. It is therefore not surprising that the leukocyte surface molecules (CD molecules) have provided targets for diagnosis and therapy. Among the "celebrities" are CD20, a target for lymphoma therapeutic antibodies which earns $2 billion annually (and makes a significant difference to lymphoma patients), and CD4, the molecule used by the human immunodeficiency virus (HIV) as an entry portal into cells of the immune system. This short review provides a background to the CD molecules and antibodies against them, and summarizes research, diagnostic, and therapeutic applications of antibodies against these molecules.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33947690177&origin=inward; http://dx.doi.org/10.2119/2006-00081.zola; http://www.ncbi.nlm.nih.gov/pubmed/17380197; https://molmed.biomedcentral.com/articles/10.2119/2006-00081.Zola; https://dx.doi.org/10.2119/2006-00081.zola; http://dx.doi.org/10.2119/2006%E2%80%9300081.zola
Springer Nature
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