Tripterine affect substance P-sensitized mast cell activity by regulating adhesion molecules and serine/threonine kinase pathway
Research Square
2022
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Objective: The aim of this research was to analyze the mechanism of tripterine anti-inflammatory and anti-allergic activity in the substance P sensitized mast cells. Methods: Substance P was used to sensitize P815 cells, and Agilent Scanner G2505C gene chip was used to analyze differential gene. The mechanism of tripterine anti-inflammatory and anti-allergic activity was analyzed by qPCR and flow cytometry. Results: Substance P significantly inhibited P815 viability, and significantly increased histamine concentration. Significance analysis showed substance P induced 1711 genes significantly up-regulated with fold change ≥ 2, and 2033 significantly down-regulated. The GO enrichment analysis showed the up-regulated differentially expressed genes (DEGs) significantly enriched in superoxide metabolic process and nucleocytoplasmic transport, and the down-regulated DEGs mainly enriched in phosphoinositide 3-kinase cascade and blood vessel remodeling. The KEGG pathway analysis found the up-regulated DEGs mainly enriched in RNA polymerase and Huntington’s disease, and the down-regulated DEGs mainly enriched in cell adhesion molecules and lysosome. Further research found that tripterine protected substance P- sensitized mast cell by regulating cell adhesion molecules and PI3K/AKT pathway. Conclusions: This study identified some key genes and pathways closely related with sensitized mast cell, and tripterine affected substance P- sensitized cell by adhesion molecules and PI3K/AKT pathway.
Bibliographic Details
Springer Science and Business Media LLC
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