Localized expression and role of full-length growth differentiation factor 15 in non-small cell lung cancer
Research Square
2022
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Purpose Growth differentiation factor 15 (GDF-15) is one of the key cachexia-inducible factors. Clinical trials on therapies targeting GDF-15 for cancer and cancer cachexia are underway. While the role of circulating GDF-15 in cachexia has been clarified, the effects of GDF-15 expression within cancer cells remain to be fully elucidated. Hence, the objective of this study was to investigate the expression of GDF-15 in advanced lung cancer tissues and to understand its role in cachexia. Methods We retrospectively examined the expression level of full-length GDF-15 in advanced non-small cell lung cancer tissues and analyzed the relationship between the staining intensity and clinical data in 53 samples. Results We found that 52.8% of the total samples were GDF-15 positive, and the GDF-15 expression significantly correlated with better nutrition and a low inflammation state. It did not correlate with the existence of cancer cachexia and overall survival. Patients with GDF-15-positive expression tended to have better survival than those with GDF-15-negative expression. Conclusion Thus, tumor GDF-15 and its family of cytokines are diverse. It is necessary to characterize their role in cancer cachexia and identify whether GDF-15 can be a predictive biomarker for cachexia in non-small cell lung cancer, which could lead to better therapeutic strategies targeting GDF-15.
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