No effect of integrated hepatitis C virus treatment on psychological distress in people with substance use disorders: results from a randomized controlled trial
Research Square
2023
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Background People with substance use disorders (SUD) have high prevalence of chronic hepatitis C virus (HCV) infection and mental health disorders. We aimed to assess the impact of integrated HCV treatment on psychological distress measured by Hopkins-symptom-checklist-10 (SCL-10). Methods This multi-center randomized controlled trial evaluated psychological distress as secondary outcomes of integrated HCV treatment (INTRO-HCV trial). From 2017 to 2019, 289 participants were randomly assigned to receive either integrated or standard HCV treatment with direct-acting antiviral therapy. Integrated HCV treatment was delivered in eight decentralized outpatient opioid agonist therapy clinics and two community care centers; standard treatment was delivered in internal medicine outpatient clinics at centralized hospitals. Participants in integrated treatment arm had a sustained virologic response of 93% compared to 73% for those in standard treatment arm. Psychological distress was assessed using SCL-10 prior to initiation of HCV treatment and 12 weeks after treatment completion. A linear mixed model was applied to evaluate the impact of integrated HCV treatment on changes in the mean SCL-10 (ΔSCL-10) score. Results The mean SCL-10 score prior to HCV treatment was 2.2 (standard deviation [SD]: 0.7) for patients receiving integrated HCV treatment and 2.1 (SD: 0.7) for those receiving standard HCV treatment. Twelve weeks after the end of treatment, the mean SCL-10 score was 2.2 (SD: 0.8) for participants receiving integrated HCV treatment and 2.1 (SD: 0.7) for those receiving standard HCV treatment. Conclusions Psychological distress did not substantially change during the treatment period and was not significantly different between the treatment arms.
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