Analytical method validation and quantitation of 3-fucosyllactose in Korean maternal milk by mass spectrometry
Research Square
2023
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
The concentration of human milk oligosaccharides has gained significant attention recently due to their positive effects on infant health. However, the concentration of 3-fucosyllactose(3-FL) in Korean mother milk has not been studied. Therefore, this study aimed to analyze the concentration of 3-FL in Korean human milk using mass spectrometry. The analytical method for quantitating 3-FL was validated to have high precision, accuracy, linearity, specificity, stability, recovery, and reproducibility. The concentration of 3-FL was then determined in 102 Korean human milk samples. The results showed that the 3-FL concentration increased during lactation, with values of 1.0, 1.1, and 1.8 g/L in 0–30, 30–60, and > 60 postpartum days, respectively. Notably, the 3-FL level in secretors (1.3 g/L, n = 80) was significantly lower than in non-secretors (2.8 g/L, n = 24). These findings provide useful information for future research, as well as for setting the recommended nutrient intake (RNI) value and formulating baby food composition.
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