The association between serum sodium variation during Pediatric Intensive Care Unit admission and the risk of clinical outcomes in critically ill children: a retrospective cohort study
Research Square
2024
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
This study evaluates sodium variation during Pediatric Intensive Care Unit (PICU) admission and its association with prolonged PICU stay (≥7days) and PICU mortality. Data from 966 critically ill pediatrics (2019-2022) with at least two sodium values available during their PICU admission were analyzed. Patients were categorized based on all recorded sodium values into normonatremia, hyponatremia, hypernatremia, and mixed dysnatremia. The difference between the highest and lowest sodium values during PICU admission was used to identify sodium fluctuation. The statistical method used was Logistic regression model. During the PICU admission, 542 patients developed dysnatremia. The PICU-acquired dysnatremia was independently associated with higher prolonged PICU stay odds after controlling for major confounders. The PICU-acquired hypernatremia (OR:5.23;95%CI:1.72-15.92) and mixed dysnatremia (OR:2.89;95%CI:1.14-7.29) had significantly higher odds of PICU mortality. However, no significant association was found between PICU-acquired hyponatremia and odds of PICU mortality. Even mild sodium fluctuations (4-8mmoL/L) during PICU admission were significantly associated with higher prolonged PICU stay odds. The highest (≥15mmol/L) fluctuations in serum sodium levels during PICU admission were also significantly associated with higher odds of PICU mortality (OR:2.74;95%CI:1.11-6.79). Our findings underscore the importance of closely monitoring serum sodium during PICU admission to improve clinical outcomes.
Bibliographic Details
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know