Effect of Neonatal Exposure of 17β-Estradiol Tamoxifen on Hepatic CYP3A Activity at Developmental Periods in Rats
Drug Metabolism and Pharmacokinetics, ISSN: 1347-4367, Vol: 19, Issue: 2, Page: 96-102
2004
- 6Citations
- 16Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- CrossRef5
- Captures16
- Readers16
- 16
Article Description
We evaluated hepatic CYP3A activity during development in male and female rats and the effect of neonatal exposure of 17 β -estradiol and tamoxifen. In untreated and olive oil-treated (control) rats, hepatic CYP3A activities evaluated by erythromycin metabolism in vitro increased several-fold from age 2 to 9 weeks in males. In contrast, activity in females remained at a low and constant level from 2 to 15 weeks. Exposure of 17 β -estradiol to neonates at a dose of 10 μ mol Wkg daily for 3 days on day 1 ~ 3 or 4 ~ 6 after birth significantly increased hepatic CYP3A activity during the developmental period in both males and females, and a greater influence was observed in females exposed during days 4 ~ 6. Pubertal exposure of 17 β -estradiol (7-weeks old, 10 μ mol Wkg daily for 3 days) also increased hepatic CYP3A activity, but only in females. Neonatal exposure to tamoxifen (10 μ mol Wkg daily for 3 days) showed no appreciable effect in either males or females. In conclusion, a marked sex-difference was observed in hepatic CYP3A activity, and exposure of 17 β -estradiol to neonates increased hepatic CYP3A activity during the developmental period, especially in female rats.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S134743671530803X; http://dx.doi.org/10.2133/dmpk.19.96; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=16544377763&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15499175; http://linkinghub.elsevier.com/retrieve/pii/S134743671530803X; https://dx.doi.org/10.2133/dmpk.19.96
Japanese Society for the Study of Xenobiotics
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know