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Synthesis of 1,3,5-Trisubstituted Pyrazole-4-Carboxylates Through 1,3-Dipolar Cycloaddition of Nitrilimines with Allenoates

SSRN Electronic Journal
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Usage
    142
    • Abstract Views
      111
    • Downloads
      31

Article Description

A strategy for the 1,3-dipolar cycloaddition of nitrilimines to δ-allenoates has been developed to provide various 1,3,5-trisubstituted pyrazole-4-carboxylates and pyrazole-4 -carboxamide derivatives, which have been reported to have excellent anticancer effects. This protocol exhibits characteristics of good yield, mild reaction condition, facile operation process and post-processing steps, as well as moderate tolerance to various functional groups.

Bibliographic Details

yulin wang; Cheng Xiong; Jiacheng Zhong; Qingfa Zhou

Elsevier BV

1; 3-dipolar cycloaddition; 3; 5-trisubstituted pyrazole-4-carboxylates; anticancer effects

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