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Nmda Receptor Antagonist Mk801 Reduces Dendritic Spine Density and Stability in Zebrafish Pyramidal Neurons

SSRN Electronic Journal
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  • 200
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Metric Options:   Counts1 Year3 Year

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  • Usage
    200
    • Abstract Views
      165
    • Downloads
      35

Article Description

NMDA-type glutamate receptors play a critical role in activity-dependent neurite growth. We employed cell type-specific genetic labeling in zebrafish to examine the effects of NMDA receptor antagonism on the morphological development of tectal pyramidal neurons (PyrNs). Our data demonstrate that the NMDA receptor antagonist MK801 reduces PyrN spine density and stability without altering dendritic growth and branching. However, the axons that synapse onto PyrN dendritic spines do exhibit reduced arbor growth and branching in response to MK801 treatment. Axons that synapse with PyrNs, but not on spines, are unaffected by MK801 treatment. These findings suggest a fundamentally different role for NMDARs during the development of spiny versus aspiny dendrites.

Bibliographic Details

Amanda Lamarca Dela Plata; Estuardo Robles

Elsevier BV

Development; Visual system; activity-dependent; neuronal morphology

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