New Cu(Ii), Ni(Ii) and Zn(Ii) Mixed Ligand Complexes Containing N-Isonicotinamido-Thiophene-2-Carbaldimine and 2-Aminophenol: Access for Promising Antibacterial and Antioxidant Agents, Dft and Molecular Docking Investigation
SSRN, ISSN: 1556-5068
2022
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- 1Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
New mixed ligand complexes of Cu(II), Ni(II), and Zn(II) with N-Isonicotinamido-Thiophene-2-Carbaldimine (L1) and 2-aminophenol (L2) have been prepared. Complex structures have been established using FT-IR, UV-vis, ESI-MS, molar conductivity studies and elemental analysis. The ligand (L1) showed coordination to the metal ions in the bidentate manner through the oxygen of the carbonyl group and nitrogen of the azomethine group. Magnetic moment values coupled with UV-visible spectra confirmed square planar structure of Ni(II) complex and on the other hand, tetrahedral structure for Cu(II) and Zn(II) complexes. The metal complexes of L1 were tested against Escherichia coli and Pseudomonas sp. Among the tested compounds, Cu(II)complex showed higher antibacterial activity over only Pseudomonas sp . bacterial strain against reference drug kanamycin.Moreover, synthesized metal complexes exhibited moderate antioxidant activity than the Schiff base. Cu(II) complex was found to be most active whereas, Zn(II) complex showed the lowest antioxidantactivity comparable to the BHT. The current metal complexes were theoretically investigated using DFT calculation through 3D structural optimization and molecular orbital’s evaluation. Furthermore, their antimicrobial and antioxidant activities were analyzed using molecular docking approach.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85127673186&origin=inward; http://dx.doi.org/10.2139/ssrn.4055049; https://www.ssrn.com/abstract=4055049; https://dx.doi.org/10.2139/ssrn.4055049; https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4055049; https://ssrn.com/abstract=4055049
Elsevier BV
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