IL-12B and IL-17 Genes Polymorphisms are Associated with Different Susceptibility to Juvenile Idiopathic Arthritis and Juvenile-Onset Systemic Lupus Erythematosus In Chinese Children
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Article Description
Objective: Genetic factors play a crucial role in the immune response of juvenile idiopathic arthritis (JIA) and juvenile-onset systemic lupus erythematosus (JSLE). This study aimed to investigate the association of IL-12B (rs3212227, rs6887695) and IL-17 (rs2275913, rs763780) gene polymorphisms with the susceptibility of JIA and JSLE in Chinese children. Methods: A total of 303 healthy controls and 304 patients including 160 JIA and 144 patients were analyzed, and the genetic polymorphisms were genotyped by using a Sequenom MassArray system. Results: There was a significant association between the IL-12B rs3212227 genotype and the increased risk of JSLE (p = 0.01). For rs6887695, the minor allele C was significantly correlated with the increased risk of JIA (odds ratio = 1.48, 95% CI = 1.12-1.95, p = 0.005). Moreover, rs6887695 genotype was significantly associated with both JIA and JSLE susceptibility (p <0.05). Besides, IL-12B haplotype block GC significantly correlated with the increased risk of JIA (p = 0.0428). However, no significant difference was found between the IL-17 (rs2275913, rs763780) gene polymorphisms and JIA or JSLE susceptibility (p >0.05). And similar genotype distributions of IL-12B and IL-17 polymorphisms were found between the patients with nephritis and without nephritis in JSLE (p >0.05). Conclusions: Our results indicated that IL-12B polymorphisms was associated with JIA and JSLE in Chinese children, and provided evidence for genetic interaction between IL-12B rs3212227 and rs6887695 in determining the development of JIA, highlighting the involvement of inflammation in the pathogenesis of JIA and JSLE.
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