Imprinted Polymer Beads Featuring Both Predefined Multiple-Point Interaction and Accessible Binding Sites for Precise Recognition of 2’-Deoxyadenosine
SSRN, ISSN: 1556-5068
2022
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
“Tailor-made” formation of complementary binding sites via lock-and-key molecular binding mechanism is critical for selective adsorption of target molecules in environmental and chemical engineering fields. However, an innovative design of a molecularly imprinted polymers (MIPs) featuring both predefined multiple-point interaction and accessible binding sites still remains a challenging task. Herein, MIPs beads (PC-MIPs) consisting of photo-crosslinked functional polymer building blocks from methacrylic acid (MAA), 1-(vinylbenzyl) thymidine (VBT) and post-crosslinking monomer cinnamoyloxyethyl methacrylate (CEMA) were easily fabricated by emulsion droplet micro-reactors, and then their precise identification of 2’-deoxyadenosine (dA) was studied by batch mode adsorption. PC-MIPs microspheres exhibited surface pores and interconnected chambers, and the internal foam-like framework may be caused by the adequate encapsulation of bubbles from low-boiling separation phase. Due to the high density of accessible imprinted sites and strong interaction with dA, over 67% of dA was captured within the initial 20 h.The maximum monolayer adsorption capacity of PC-MIPs was calculated to be 134.5 μmol g -1 for dA, surpassing most of the reported dA-imprinted sorbents. High-affinity sites from Scatchard analysis accounted for about 64.08% of total binding sites, suggesting the synergy of predefined multiple-point interaction from double monomers and imprinting effect. In addition, PC-MIPs also showed good selectivity (imprinting factor above 2.71) and high stability, as well as excellent recyclability toward dA. Moreover, 82.4% of dA was extracted by PC-MIPs from spiked human urine samples, owing to the advantage of post-crosslinking strategy enabling more stable interaction between the template molecules and functional polymers. Therefore, our work demonstrated an alternate strategy to design polymers bearing precise molecular recognition capability, and provided a new perspective for dA enrichment from biological samples.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85176970235&origin=inward; http://dx.doi.org/10.2139/ssrn.4138997; https://www.ssrn.com/abstract=4138997; https://dx.doi.org/10.2139/ssrn.4138997; https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4138997; https://ssrn.com/abstract=4138997
Elsevier BV
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