Sex Differences in Predictors of Recurrence after Catheter Ablation in Patients with Persistent Atrial Fibrillation
SSRN Electronic Journal
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Background: Atrial fibrillation (AF) is a progressive disease, and patients with persistent AF (PeAF) have consistent long-term recurrences after AF catheter ablation (AFCA). We explored the possible sex-related differences in the recurrence predictors in patients with PeAF who had a recurrence within 3 years after AFCA. Methods: Among 3985 consecutive patients who underwent a de novo AFCA and protocol-based rhythm follow-up, we evaluated the predictors of an AF clinical recurrence within 3 years (CR-3yr) of the AFCA in 1387 patients with PeAF (men: 78.4%, 59.510.5 years old), in relation to the sex of the patients. Results: The left atrial (LA) dimension (hazard ratio [HR] 1.04 [1.02-1.06], p=0.001) and LA voltage (HR 0.71 [0.58-0.87], p=0.001) were independently associated with a CR-3yr of the AFCA of PeAF. Among 1088 men, the LA dimension (HR 1.04 [1.01-1.07], p=0.006), an epicardial adipose tissue (EAT) volume ≥ the median (HR 1.37 [1.04-1.80], p=0.025), and LA voltage (HR 0.64 [0.51-0.80], p<0.001) were independent predictors of a CR-3yr. In 299 women, diabetes was independently associated with a CR-3yr (HR 0.48 [0.25-0.93]), p=0.03). There were significant interactions between the sex and effects of the age (P for interaction=0.042) and EAT (P for interaction=0.022) on the CR-3yr. In contrast, there were no significant sex differences in the CR-3yr risk factors in patients with paroxysmal AF. Conclusions: A large EAT volume was associated with a higher CR-3yr, especially in males after PeAF ablation. The absence of diabetes in women was independently associated with AF recurrence after PeAF ablation.
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