PlumX Metrics
Embed PlumX Metrics

Efficacy of a Toothpaste Containing Paeonol, Potassium Nitrate, and Strontium Chloride on Dentine Hypersensitivity: A Double-Blind Randomized Controlled Trial in Chinese Adults

SSRN, ISSN: 1556-5068
2022
  • 0
    Citations
  • 463
    Usage
  • 0
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Usage
    463
    • Abstract Views
      415
    • Downloads
      48

Article Description

Objective: The aim of this randomized controlled trial was to compare the efficacy of a toothpaste containing paeonol, potassium nitrate, and strontium chloride with control toothpaste on dentine hypersensitivity. Methods: A total of 90 eligible subjects were included and divided into two groups: the test group, using a toothpaste containing paeonol, potassium nitrate, and strontium chloride; and a control group, using a placebo toothpaste. The participant’s DH was evaluated at baseline, and after 4 and 8 weeks of dentifrice application using airblast and tactile tests. Results: Of all included subjects, 88 completed all visits. In both groups, the Yeaple probe score showed an upward trend, while the Schiff sensitivity scoreshowed a downward trend. At week 8, the Yeaple probe score had increased by30.22 g in the test group and 22.79 g in the control group, and the Schiff Index score had decreased by 0.90 in the test group and 0.72 in the control group. Compared to the control group, in the test group, the Yeaple probe score increased by 18.35%, and the Schiff Index score decreased by 17.73%, showing a statistically significant difference. Conclusion: The toothpaste containing paeonol, potassium nitrate, and strontium chloride is effective against dentine hypersensitivity.Clinical SignificanceThis combination of paeonol, potassium nitrate and strontium chloride could be a novel functional ingredient choice for anti-hypersensitivity products in future. Clinical Trial Registration Details: Registered in the Chinese Clinical Trial Registry (ChiCTR2000041417). Funding Information: This research was supported by the Exploration and R&D Project of the West China Hospital of Stomatology, Sichuan University (no.: RD-01-202105). Declaration of Interests: The authors have no conflict of interest to declare. Ethics Approval Statement: This study was approved by the Ethics Committee (WCHSIRB-D-2020-157). Before participation, the subjects signed a consent form after being informed in detail about the process, benefits and risks, and voluntary principles.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know