Efficacy of a Toothpaste Containing Paeonol, Potassium Nitrate, and Strontium Chloride on Dentine Hypersensitivity: A Double-Blind Randomized Controlled Trial in Chinese Adults
SSRN, ISSN: 1556-5068
2022
- 463Usage
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Objective: The aim of this randomized controlled trial was to compare the efficacy of a toothpaste containing paeonol, potassium nitrate, and strontium chloride with control toothpaste on dentine hypersensitivity. Methods: A total of 90 eligible subjects were included and divided into two groups: the test group, using a toothpaste containing paeonol, potassium nitrate, and strontium chloride; and a control group, using a placebo toothpaste. The participant’s DH was evaluated at baseline, and after 4 and 8 weeks of dentifrice application using airblast and tactile tests. Results: Of all included subjects, 88 completed all visits. In both groups, the Yeaple probe score showed an upward trend, while the Schiff sensitivity scoreshowed a downward trend. At week 8, the Yeaple probe score had increased by30.22 g in the test group and 22.79 g in the control group, and the Schiff Index score had decreased by 0.90 in the test group and 0.72 in the control group. Compared to the control group, in the test group, the Yeaple probe score increased by 18.35%, and the Schiff Index score decreased by 17.73%, showing a statistically significant difference. Conclusion: The toothpaste containing paeonol, potassium nitrate, and strontium chloride is effective against dentine hypersensitivity.Clinical SignificanceThis combination of paeonol, potassium nitrate and strontium chloride could be a novel functional ingredient choice for anti-hypersensitivity products in future. Clinical Trial Registration Details: Registered in the Chinese Clinical Trial Registry (ChiCTR2000041417). Funding Information: This research was supported by the Exploration and R&D Project of the West China Hospital of Stomatology, Sichuan University (no.: RD-01-202105). Declaration of Interests: The authors have no conflict of interest to declare. Ethics Approval Statement: This study was approved by the Ethics Committee (WCHSIRB-D-2020-157). Before participation, the subjects signed a consent form after being informed in detail about the process, benefits and risks, and voluntary principles.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85179566650&origin=inward; http://dx.doi.org/10.2139/ssrn.4195304; https://www.ssrn.com/abstract=4195304; https://dx.doi.org/10.2139/ssrn.4195304; https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4195304; https://ssrn.com/abstract=4195304
Elsevier BV
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