Suppress the Metastatic Properties of Cancer Stem-Like Cells (NTERA-2) Using Sox2-Oct4 Decoy Oligodeoxynucleotide−Encapsulated Niosomes-Zinc Hybrid Nanocarriers Under X-Irradiation
SSRN, ISSN: 1556-5068
2023
- 203Usage
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Article Description
Sox2 and Oct4 dysregulations could lead to an increased cancer stem cell (CSC) population in some cancer cells and resistance to common treatments. In this study, we investigated the synergistic effects of Sox2-Oct4 decoy oligodeoxynucleotides-encapsulated Niosomes-zinc hybrid nanocarriers along with X‐irradiation conditions as combinational therapy tool on cancer-like stem cells (NTERA-2). Due to technical limitations and difficulties in CSCs culture, we used the NTERA-2 cell line known as a cancer-like stem cell line in the present study. Sox2-Oct4 decoy oligodeoxynucleotides were designed based on the Sox2 gene promoter and synthesized. Physicochemical characteristics of ODNs-encapsulated niosomes-zinc hybrid nanocarriers (NISM@BSA-DEC-Zn) investigated with FT-IR, DLS, FESEM, and hemolysis assays. Further investigations such as uptake, cell viability, apoptosis, cell cycle, and scratch repair tests were done. All the above assays were performed both with and without X-rays exposure conditions (fractionated 2Gy). Physicochemical characteristics results showed that the Niosomes-Zn nanocarriers successfully were synthesized. NISM@BSA-DEC-Zn efficiently was taken up by NTERA-2 cells and significantly inhibited cell growth, increased apoptosis, and reduced cell migration in both conditions with and without X-rays exposure. Furthermore, NISM@BSA-DEC-Zn treatment resulted in G1 and G2/M cell cycle arrest without and with X-irradiation, respectively. The prepared nanocarrier system can be a promising tool for drug delivery in cancer treatment. The application of the decoy strategy along with zinc metal could increase the sensitivity of cancer cells toward irradiation, which has the potential to eliminate cancerous cells from tumors in the form of combinational therapies.
Bibliographic Details
Elsevier BV
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