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Biocompatible, Waterproof and Breathable Pdms-Based Pu Fibrous Membranes for Potential Application in Wound Dressing

SSRN, ISSN: 1556-5068
2023
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  • Usage
    173
    • Abstract Views
      142
    • Downloads
      31

Article Description

Wound dressing, a powerful tool for repairing and protecting injured skin from secondary damage, has been widely manufactured. However, the design of wound dressings with waterproofness, breathability, mechanical robustness, and outstanding biocompatibility remains a challenge owing to the imbalance between the multiple desirable properties. Herein, a strategy is proposed to fabricate biocompatible membranes via a facile one-step electrospinning method. Polydimethylsiloxane (PDMS)-based polyurethane (Si-PU) is successfully prepared to construct durable hydrophobic surfaces to endow the membrane with high hydrophobicity (water contact angle = 141.0°). The porous structure is optimized by adjusting the solution concentration and heat treatment temperature, enabling the membrane with an optimum water vapor transmission rate of 8.2 kg·m−2·h−1, a hydrostatic pressure of 52.3 kPa (approximately 14.1 times that of the PU fibrous membrane), and an enhanced tensile stress of 6.60 MPa. Furthermore, the membrane can be used within a very wide temperature range from –123°C to 160°C due to the low glass transition temperature and superior thermal stability. Importantly, both in vitro and in vivo experiments verified the excellent biocompatibility and negligible toxicity to normal cells and mice skin, as characterized by hematoxylin and eosin (H&E) and Masson staining. Our work presents a new approach for designing waterproof, and breathable, mechanical robust biomaterials and enhancing the performance and functionality of biomaterials in biomedical fields, especially in wound dressing applications.

Bibliographic Details

Yanyan Yu; Jie Zhang; Peijian Zhao; Guopeng Xu

Elsevier BV

Multidisciplinary; polydimethylsiloxane-based polyurethane; electrospinning; waterproof and breathable; biocompatibility; wound dressing

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