Polystyrene Microplastics Mitigate Lead-Induced Neurotoxicity by Reducing Heavy Metal Uptake in Zebrafish Larvae
SSRN, ISSN: 1556-5068
2024
- 118Usage
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
The combined pollution of lead (Pb) and polystyrene microplastics (PS-MPs) is common in aquatic environments. However, the combined neurotoxicity of these two pollutants is still poorly understood. In this study, zebrafish (Danio rerio) larvae were employed to assess the combined neurotoxicity and mechanism of Pb and PS-MPs, with the selected concentration being environmentally relevant. The results showed that Pb (10 μg/L) induced abnormal behavior including significantly reduced movement distance, maximum acceleration, and average velocity (P < 0.05), and altered expression of neurodevelopment-related genes (gap43 and α1-tubulin) (P < 0.05). The neurotoxicity caused by Pb was alleviated by addition of PS-MPs (25 μg/L, 250 μg/L; diameter at 25 μm), not only because PS-MPs significantly reduced the concentration of Pb in the exposed solution (P < 0.01), but also decreased the uptake of Pb by downregulating the divalent metal transporter 1 gene (dmt1). However, upregulation of dmt1 by addition of deferoxamine (DFO, an efficient iron chelator, 100 μM) significantly increased the Pb uptake and exacerbating neurotoxicity in zebrafish. In summary, our results demonstrated that PS-MPs alleviate Pb neurotoxicity by downregulating the mRNA level of dmt1 and decreasing the Pb uptake. This study provides a new understanding of the combined neurotoxicity and underlying mechanisms of PS-MPs and Pb on zebrafish.
Bibliographic Details
Elsevier BV
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