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Modelling the Cost-Effectiveness of Cervical Cancer Screening with Hpv Self-Sampling and Molecular Triage for Women Aged 60-69 Years

SSRN, ISSN: 1556-5068
2024
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Article Description

Objective The aim of this cost-effectiveness analysis is to, from a health economics perspective, compare the current Swedish national cervical screening program for women aged 60-69 years with self-sampling and molecular triage strategies.Methods Based on data from a Swedish population-based cervical screening study, current screening is compared with modelled molecular triage strategies in a cost-effectiveness analysis. The comparison is made with respect to healthcare resource use measured as total costs and health effects, measured as number of identified high-grade squamous intraepithelial lesions (HSIL).Results Screening with molecular triage either leads to decreases in effect or significant cost increases due to higher rate of HPV-positive screening samples and higher number of colposcopies.Conclusions Molecular triage, whether screening is based on self-sampling or professional sampling, does not appear to be cost-effective in this age group compared to the currently implemented strategy with cytological triage.

Bibliographic Details

Lovisa Bergengren; Gabriella Lillsunde-Larsson; Jasmine Fridljung; Linda Ryen

Elsevier BV

Multidisciplinary; Cost-effectiveness; economic evaluation; cervical screening; HPV; self-sampling; methylation; genotyping

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