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Aryl/Hetero-Aryl Tosylates as Coupling Partners in Metal Mediated Suzuki and Hiyama Cross-Coupling Reactions in Ionic Liquids: Facile Synthesis of Biaryls/Heterobiaryls

SSRN, ISSN: 1556-5068
2024
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  • Usage
    115
    • Abstract Views
      100
    • Downloads
      15

Article Description

Diverse libraries of biaryls/heterobiaryls were synthesized by aryl/hetero-aryl tosylates as coupling partners in the ligand-free, Ni-catalyzed Suzuki coupling reaction and Pd-catalysed Hiyama cross-coupling reaction in ionic liquids (ILs) as green solvent. In this method easily available and economically viable Tosylates were coupled with readily available boronic acids and phenyltriethoxysilanes in Suzuki and Hiyama cross-coupling respectively to yield the corresponding biaryls/heterobiaryls. Mild reaction condition(s), easy workup, moderate to excellent yield of the isolated pure products, wide substrate scope, and recycling/reuse of the ILs are the advantages of this method over the other reported methods.

Bibliographic Details

Vinod S. Jadhav; Sunita Kurahatti; Athmanand Anchi; Imamhusen Jamadar; Rajesh Gurunath Kalkhambkar; Suraj M. Sutar; Mahaveer Kurkuri

Elsevier BV

Multidisciplinary; aryl/hetero-aryl tosylates; Biaryls; Cross-Coupling Reactions; green chemistry; Ionic Liquids

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