PlumX Metrics
Embed PlumX Metrics

Preparation and Evaluation of Curcumin Derivatives Nanoemulsion Based on Turmeric Extract and Its Antidepressant Effect

International Journal of Nanomedicine, ISSN: 1178-2013, Vol: 18, Page: 7965-7983
2023
  • 2
    Citations
  • 0
    Usage
  • 22
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Purpose: The early stage of this study verified that a turmeric extract (TUR) including 59% curcumin (CU), 22% demethoxycurcu-min (DMC), and 18% bisdemethoxycurcumin (BDMC), could enhance the stability of CU and had greater antidepressant potential in vitro. The objective of the study was to develop a nano-delivery system containing TUR (TUR-NE) to improve the pharmacokinetic behavior of TUR and enhance its antidepressant effect. Methods: The antidepressant potential of TUR was explored using ABTS, oxidative stress-induced cell injury, and a high-throughput screening model. TUR-NE was fabricated, optimized and characterized. The pharmacokinetic behaviors of TUR-NE were evaluated following oral administration to normal rats. The antidepressant effect of TUR-NE was assessed within chronic unpredictable mild stress model (CUMS) mice. The behavioral and biochemical indexes of mice were conducted. Results: The results depicted that TUR had 3.18 and 1.62 times higher antioxidant capacity than ascorbic acid and CU, respectively. The inhibition effect of TUR on ASP+ transport was significantly enhanced compared with fluoxetine and CU. TUR-NE displayed a particle size of 116.0 ± 0.31 nm, polydispersity index value of 0.121 ± 0.007, an encapsulation rate of 98.45%, and good release and stability in cold storage. The results of pharmacokinetics indicated the AUC of TUR-NE was 8.436 and 4.495 times higher than that of CU and TUR, while the C was 9.012 and 5.452 times higher than that of CU and TUR, respectively. The pharmacodynamic study confirmed that the superior antidepressant effect of TUR-NE by significantly improving the depressant-like behaviors and elevating the content of 5-hydroxytryptamine in plasma and brain in CUMS mice. TUR-NE showed good safety with repeated administration. Conclusion: TUR-NE, which had small and uniform particle size, enhanced the bioavailability and antidepressant effect of TUR. It could be a promising novel oral preparation against depression.

Bibliographic Details

Sheng, Lin; Wei, Yumeng; Pi, Chao; Cheng, Ju; Su, Zhilian; Wang, Yuanyuan; Chen, Tao; Wen, Jie; Wei, Yuxun; Ma, Jingwen; Tang, Jia; Liu, Huiyang; Liu, Zerong; Shen, Hongping; Zuo, Ying; Zheng, Wenwu; Zhao, Ling

Informa UK Limited

Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Materials Science; Pharmacology, Toxicology and Pharmaceutics; Chemistry

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know