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Amisulpride: A first-line option in the management of schizophrenia

Drugs and Therapy Perspectives, ISSN: 1172-0360, Vol: 18, Issue: 7, Page: 1-4
2002
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Article Description

Amisulpride is an atypical antipsychotic that is specific for dopamine D and D receptors. It is as effective as haloperidol, flupenthixol and risperidone in reducing overall and positive symptoms in patients with acute exacerbations of schizophrenia with predominant positive symptoms. It tended to be more effective than other agents in alleviating negative symptoms and provided better control of affective symptoms. Amisulpride is also effective for long-term maintenance therapy in patients with chronic schizophrenia with positive or mixed positive and negative symptoms. In addition, it improves quality of life and social functioning in patients with chronic schizophrenia when given long term. In common with other atypical agents, amisulpride has less propensity to induce extrapyramidal effects than conventional antipsychotics. Amisulpride has minimal neurocardiac effects and a low potential for drug interactions.

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