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Does pharmacodynamics of drugs change after presenting them as na-noparticles like their pharmacokinetics?

Current Drug Targets, ISSN: 1873-5592, Vol: 21, Issue: 8, Page: 807-818
2020
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Review Description

Nowadays, the breakthrough in different medical branches makes it feasible to designate new methods of drug delivery to achieve the most cost-effective and the least unpleasant consequence-imposing solutions to overcome a wide range of diseases. Nanoparticle (NP) drugs entered the therapeutic system, especially in cancer chemotherapy. These drugs are quite well-known for two traits of being long-acting and less toxic. For a long time, it has been investigated how NPs will change the kinetics of drugs. However, there are a few studies that in-clined their attention to how NPs affect the dynamics of drugs. In this review, the latter point will mainly be discussed in an example-based manner. Besides, other particular features of NPs will be briefly noted. NPs are capable of affecting the biologic system as much as a drug. Moreover, NPs could arise a wide variety of effects by triggering their own receptors. NPs are able to change a receptor function and manipulate its downstream signaling cascade.

Bibliographic Details

Mohammad Jafari, Razieh; Ala, Moein; Goodarzi, Navid; Dehpour, Ahmad Reza

Bentham Science Publishers Ltd.

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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