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Penetration of infectious prion protein in the intestine during the lactation period

Mini-Reviews in Organic Chemistry, ISSN: 1570-193X, Vol: 9, Issue: 1, Page: 27-30
2012
  • 1
    Citations
  • 0
    Usage
  • 9
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1
    • Citation Indexes
      1
      • CrossRef
        1
  • Captures
    9

Article Description

Prion diseases are fatal neurodegenerative zoonotic foodborne disorders, which are caused by an abnormal isoform of prion protein (PrP) derived from the cellular isoform of prion protein (PrP). According to epidemiological surveillance and in vivo experiments, exposure to the PrP during the weaning period is fraught with risk, suggesting that, during development, the intestinal defenses and the immune system are involved in PrP infection susceptibility. Although it remains unclear how PrP passes through the natural biological barriers during its invasion of intestinal cells, the 37 kDa/67 kDa laminin receptor is suspected to be one of the receptors involved in PrP-incorporation. In addition, we have recently shown that the neonatal Fc receptor (nFcR), which contributes to the uptake of maternal antibodies into the intestine, may play an important role in PrP incorporation. In this review, recent studies on PrP uptake and models of PrP incorporation into the intestine via the laminin and Fc receptors are described. © 2012 Bentham Science Publishers.

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