Evaluation of Antibacterial and Antibiofilm Activities of Fennel Seed Extract Against Methicillin-resistant Staphylococcus aureus
Current Bioactive Compounds, ISSN: 1875-6646, Vol: 20, Issue: 2
2024
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
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Article Description
Background: Antimicrobial resistance against pathogenic bacterial strains is the current problem faced by the world. Medicinal plants are being focussed for new alternatives to routine antibiotics for novel therapeutic and antimicrobial approaches. Objective: In this present study, fennel extract from Foeniculum vulgare plant was investigated against methicillin-resistant Staphylococcus aureus (MRSA). Method: Ethanol extraction of fennel seeds was performed and minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and time-kill curve was studied to find antimi-crobial activities. Biofilm eradication was estimated by crystal violet assay. Result: Antimicrobial study showed a MIC of 500 μg/ml and MBC of 1000 μg/ml for fennel ex-tract. Sub-inhibitory concentrations (½ MIC and ¾ MIC) started to kill bacterial cells after the addition of fennel extract at mid-log phase of growth. Test phytochemical eradicated 38.7%, 62.2%, and 76.9% of MRSA biofilm from microtitre plate when added at a concentration of 250 μg/ml, 375 μg/ml and 500 μg/ml, respectively. Conclusion: This study showed different bactericidal and antibiofilm activity of fennel seed extract against MRSA. We suggested that the phytocompound could be a promising candidate and further investigation is needed to isolate the active component of the extract for the management of MRSA.
Bibliographic Details
Bentham Science Publishers Ltd.
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