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Hyper-Eosinophilic Syndrome with Myocarditis after Inactivated SARS-CoV-2 Vaccination-A Case Study

Current Drug Safety, ISSN: 1574-8863, Vol: 18, Issue: 1, Page: 103-106
2023
  • 7
    Citations
  • 0
    Usage
  • 29
    Captures
  • 1
    Mentions
  • 38
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    7
  • Captures
    29
  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    38
    • Shares, Likes & Comments
      38
      • Facebook
        38

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Hyper-eosinophilic syndrome with myocarditis after inactivated SARS-CoV-2 vaccination – a case study

This article was originally published here Curr Drug Saf. 2022 May 9. doi: 10.2174/1574886317666220509165317. Online ahead of print. ABSTRACT INTRODUCTION: COVID-19 vaccine induced serious adverse

Article Description

Introduction: COVID-19 vaccine-induced serious adverse reactions are rare. Hyper-eosinophilia syndrome with myocarditis has not been reported earlier following BBV152 vaccine administration. Case Presentation: A young man without any co-morbidities presented with persistent periorbital swelling along with itchy swelling over fingers, resting tachycardia, and exertional breathlessness following the first dose of an inactivated SARS-CoV-2 vaccine (BBV152, COVAXIN). On inves-tigation, the patient had elevated blood eosinophils (maximum 21.5% with an absolute eosinophil count of 2767/mm) and myocarditis (Lake Louise Criteria). He was successfully treated with ster-oids and supportive treatment. Conclusion: This is the first reported case of hyper-eosinophilia syndrome after COVAXIN ad-ministration. Prior history of the allergic disease may be a predisposing factor in this case. Hyper-eosinophilia can present with variable symptoms. In the current case, myocarditis was present with persistent resting tachycardia and dyspnea. Steroid and antiallergic drugs may be successful for the treatment of vaccine-induced hyper-eosinophilia with myocarditis. Increased vigilance is needed for such adverse events.

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