Plasma volume, albumin, and fluid status in peritoneal dialysis patients
Clinical Journal of the American Society of Nephrology, ISSN: 1555-9041, Vol: 5, Issue: 8, Page: 1463-1470
2010
- 110Citations
- 45Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations110
- Citation Indexes110
- 110
- CrossRef86
- Captures45
- Readers45
- 45
Article Description
Background and objectives: Peritoneal dialysis (PD) patients may be overhydrated especially when inflammation is present. We hypothesized that patients with a plasma albumin below the median value would have measurable overhydration without a proportional increase in plasma volume (PV). Design, setting, participants, & measurements: We investigated a cross-sectional sample of 46 prevalent PD patients powered to detect a proportional increase in PV associated with whole body overhydration and hypoalbuminemia. PV was determined from I-labeled albumin dilution, absolute total body water from D dilution (TBW), and relative hydration from multifrequency bioimpedance analysis (BIA; Xitron 4200) expressed as the extracellular water (ECW):TBW ratio. Results: Whereas patients with plasma albumin below the median (31.4 g/dl) were overhydrated as determined both by BIA alone (ECW:TBW 0.49 versus 0.47, P < 0.036) and the difference between estimated TBW and measured TBW (3.55 versus 0.94 L, P = 0.012), corrected PV was not different (1463 versus 1482 ml/m, NS). Mean PV was not different from predicted, and its variance did not correlate with any other clinical measures. Multivariate analysis showed that the only independent predictor of whole body overhydration was reduced plasma albumin. Conclusions: Hypoalbuminemia is an important determinant of tissue overhydration in PD patients. This overhydration is not associated with an increased plasma volume. Attempts to normalize the ECW:TBW ratio in hypoalbuminemic, inflamed PD patients may lead to hypovolemia and loss of residual renal function. Copyright © 2010 by the American Society of Nephrology.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955719794&origin=inward; http://dx.doi.org/10.2215/cjn.09411209; http://www.ncbi.nlm.nih.gov/pubmed/20538836; https://journals.lww.com/01277230-201008000-00017; http://cjasn.asnjournals.org/cgi/doi/10.2215/CJN.09411209; https://syndication.highwire.org/content/doi/10.2215/CJN.09411209; https://dx.doi.org/10.2215/cjn.09411209; https://journals.lww.com/cjasn/Fulltext/2010/08000/Plasma_Volume,_Albumin,_and_Fluid_Status_in.17.aspx; https://cjasn.asnjournals.org/content/5/8/1463; https://cjasn.asnjournals.org/content/5/8/1463.abstract; https://cjasn.asnjournals.org/content/5/8/1463.full.pdf; http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.09411209; http://cjasn.asnjournals.org/content/5/8/1463; https://cjasn.asnjournals.org/content/clinjasn/5/8/1463.full.pdf
Ovid Technologies (Wolters Kluwer Health)
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