PlumX Metrics
Embed PlumX Metrics

Plasma volume, albumin, and fluid status in peritoneal dialysis patients

Clinical Journal of the American Society of Nephrology, ISSN: 1555-9041, Vol: 5, Issue: 8, Page: 1463-1470
2010
  • 110
    Citations
  • 0
    Usage
  • 45
    Captures
  • 0
    Mentions
  • 3
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    110
  • Captures
    45
  • Social Media
    3
    • Shares, Likes & Comments
      3
      • Facebook
        3

Article Description

Background and objectives: Peritoneal dialysis (PD) patients may be overhydrated especially when inflammation is present. We hypothesized that patients with a plasma albumin below the median value would have measurable overhydration without a proportional increase in plasma volume (PV). Design, setting, participants, & measurements: We investigated a cross-sectional sample of 46 prevalent PD patients powered to detect a proportional increase in PV associated with whole body overhydration and hypoalbuminemia. PV was determined from I-labeled albumin dilution, absolute total body water from D dilution (TBW), and relative hydration from multifrequency bioimpedance analysis (BIA; Xitron 4200) expressed as the extracellular water (ECW):TBW ratio. Results: Whereas patients with plasma albumin below the median (31.4 g/dl) were overhydrated as determined both by BIA alone (ECW:TBW 0.49 versus 0.47, P < 0.036) and the difference between estimated TBW and measured TBW (3.55 versus 0.94 L, P = 0.012), corrected PV was not different (1463 versus 1482 ml/m, NS). Mean PV was not different from predicted, and its variance did not correlate with any other clinical measures. Multivariate analysis showed that the only independent predictor of whole body overhydration was reduced plasma albumin. Conclusions: Hypoalbuminemia is an important determinant of tissue overhydration in PD patients. This overhydration is not associated with an increased plasma volume. Attempts to normalize the ECW:TBW ratio in hypoalbuminemic, inflamed PD patients may lead to hypovolemia and loss of residual renal function. Copyright © 2010 by the American Society of Nephrology.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know