Preptin as a Potential Marker in Iraqi Newly Diagnosed T2DM and T2DM with Cardiovascular Disease

Background: Diabetes mellitus has become one of the world’s most typical and costly chronic diseases. Diabetes mellitus and cardiovascular disease, which is the primary reason for morbidity and death among diabetic individuals. The aim of present work is to study the Role of preptin level in Iraqi type 2 diabetes patients and related with other biochemical parameters. Methods: This study was including (88) partespents, (22) newly diagnosed T2DM, (22) T2DM and (22) ischemic heart disease with T2DM, and (22) as healthy control, age ranged (35–63) years. Results: The findings indicate that individuals with type 2 diabetes mellitus (T2DM) exhibited markedly elevated levels of FBS, HbA1C, insulin, HOMA-IR, TC, TG, LDL-C, VLDL-C, and preptin in comparison to the control group. These differences were statistically significant (P < 0.0001). Moreover, the Pearson correlation analysis revealed that preptin levels were positively associated with FBS, HbA1c, TC, TG, LDL, VLDL, insulin, and HOMA-IR while exhibiting a negative correlation with HDL. Conclusion: Because preptin plays a critical function in controlling sugar metabolism and, consequently, sugar problems, excessive levels of preptin play a significant role in the patient’s inability to control both their level of glycosylated hemoglobin and their blood sugar levels. preptin levels are therefore high in diabetics and those with heart disease, which results in a loss of control over the body’s metabolism and exposes a patient to many other ailments.