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Objectively measured sedentary time may predict insulin resistance independent of moderate- and vigorous-intensity physical activity

Diabetes, ISSN: 0012-1797, Vol: 58, Issue: 8, Page: 1776-1779
2009
  • 192
    Citations
  • 0
    Usage
  • 219
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    192
    • Citation Indexes
      189
    • Policy Citations
      2
      • Policy Citation
        2
    • Clinical Citations
      1
      • PubMed Guidelines
        1
  • Captures
    219
  • Mentions
    1
    • News Mentions
      1
      • News
        1

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Article Description

OBJECTIVE - To examine the prospective association between objectively measured time spent sedentary and insulin resistance and whether this association is independent of moderate- and vigorous-intensity physical activity (MVPA) and other relevant confounders. RESEARCH DESIGN AND METHODS - This was a population-based study (Medical Research Council Ely study) in 376 middle-aged adults (166 men; 210 women) over 5.6 years of follow-up. Physical activity and sedentary time were measured objectively by individually calibrated minute-by-minute heart rate monitoring at both baseline and follow-up. Sedentary time was calculated as the heart rate observations (in minutes) below an individually predetermined threshold (flex heart rate) and expressed as a percentage of total monitored time during waking hours over 4 days. The percentage of time spent above 1.75 x resting heart rate represented MVPA. Fasting plasma insulin was used as a surrogate measure of insulin resistance. RESULTS - Time spent sedentary at baseline was significantly and positively associated with log fasting insulin at follow-up (β = 0.003, 95% CI 0.0006-0.006, P = 0.015) independent of baseline age, sex, fat mass, fasting insulin, smoking status, and follow-up time. After further adjustment for MVPA, this association was somewhat strengthened (β = 0.004, 95% CI 0.0009-0.006, P = 0.009). CONCLUSIONS - Time spent sedentary predicts higher levels of fasting insulin independent of the amount of time spent at moderate- and vigorous-intensity activity levels. This highlights the importance of reducing sedentary time in order to improve metabolic health, possibly in addition to the benefits associated with a physically active lifestyle. © 2009 by the American Diabetes Association.

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