A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: A randle cycle favoring fat storage
Diabetes, ISSN: 0012-1797, Vol: 62, Issue: 2, Page: 362-372
2013
- 42Citations
- 69Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations42
- Citation Indexes42
- 42
- CrossRef34
- Captures69
- Readers69
- 69
Article Description
Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catchup fat, we previously reported that during refeeding on a low-fat diet, glucose tolerance is normal but insulin-dependent glucose utilization is decreased in skeletal muscle and increased in adipose tissue, where de novo lipogenic capacity is concomitantly enhanced. Here we report that isocaloric refeeding on a high-fat (HF) diet blunts the enhanced in vivo insulin-dependent glucose utilization for de novo lipogenesis (DNL) in adipose tissue. These are shown to be early events of catch-up growth that are independent of hyperphagia and precede the development of overt adipocyte hypertrophy, adipose tissue inflammation, or defective insulin signaling. These results suggest a role for enhanced DNL as a glucose sink in regulating glycemia during catch-up growth, which is blunted by exposure to an HF diet, thereby contributing, together with skeletal muscle insulin resistance, to the development of glucose intolerance. Our findings are presented as an extension of the Randle cycle hypothesis, whereby the suppression of DNL constitutes a mechanism by which dietary lipids antagonize glucose utilization for storage as triglycerides in adipose tissue, thereby impairing glucose homeostasis during catch-up growth. © 2013 by the American Diabetes Association.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84873050572&origin=inward; http://dx.doi.org/10.2337/db12-0255; http://www.ncbi.nlm.nih.gov/pubmed/22961086; https://diabetesjournals.org/diabetes/article/62/2/362/15271/A-Role-for-Adipose-Tissue-De-Novo-Lipogenesis-in; https://dx.doi.org/10.2337/db12-0255; http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db12-0255; http://diabetes.diabetesjournals.org/content/62/2/362; http://diabetes.diabetesjournals.org/content/62/2/362.abstract; http://diabetes.diabetesjournals.org/content/62/2/362.full.pdf; https://diabetes.diabetesjournals.org/content/62/2/362; https://diabetes.diabetesjournals.org/content/62/2/362.abstract; https://diabetes.diabetesjournals.org/content/diabetes/62/2/362.full.pdf; http://europepmc.org/abstract/med/22961086; http://europepmc.org/articles/PMC3554390
American Diabetes Association
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