Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity
Diabetes, ISSN: 1939-327X, Vol: 72, Issue: 8, Page: 1083-1094
2023
- 8Citations
- 9Captures
- 1Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations8
- Citation Indexes8
- Captures9
- Readers9
- Mentions1
- News Mentions1
- 1
Most Recent News
Researcher at Zhejiang University School of Medicine Targets Obesity (Activation of METTL3 promotes white adipose tissue beiging and combats obesity)
2023 JUN 09 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity Daily News -- New research on obesity is the subject of a
Article Description
The induction of beige adipocytes in white adipose tissue (WAT), also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation of WAT beiging at the posttranscriptional level remains to be studied. Here, we report that METTL3, the methyltransferase of N6-methyladenosine (m6A) mRNA modification, is induced during WAT beiging in mice. Adiposespecific depletion of the Mettl3 gene undermines WAT beiging and impairs the metabolic capability of mice fed with a high-fat diet. Mechanistically, METTL3-catalyzed m6A installation on thermogenic mRNAs, including Kr€uppellike factor 9 (Klf9), prevents their degradation. Activation of the METTL3 complex by its chemical ligand methyl piperidine- 3-carboxylate promotes WAT beiging, reduces body weight, and correctsmetabolic disorders in diet-induced obesemice. These findings uncover a novel epitranscriptionalmechanism inWAT beiging and identifyMETTL3 as a potential therapeutic target for obesity-associated diseases.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85165521729&origin=inward; http://dx.doi.org/10.2337/db22-0775; http://www.ncbi.nlm.nih.gov/pubmed/37224383; https://diabetesjournals.org/diabetes/article/72/8/1083/151369/Activation-of-METTL3-Promotes-White-Adipose-Tissue; https://dx.doi.org/10.2337/db22-0775
American Diabetes Association
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know