Impaired endothelial function in preadolescent children with type 1 diabetes
Diabetes Care, ISSN: 0149-5992, Vol: 34, Issue: 3, Page: 681-685
2011
- 78Citations
- 65Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations78
- Citation Indexes75
- 75
- CrossRef60
- Clinical Citations3
- PubMed Guidelines3
- Captures65
- Readers65
- 65
Article Description
OBJECTIVE - We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS - We studied 21 type 1 diabetic children (aged 8.3±0.3 years with diabetes duration of 4.3±0.4 years) and 15 group-matched healthy siblings (aged 7.6 ± 0.3 years). Fasting plasma glucose (FPG), lipid profile, HbA , high-sensitivity C-reactive protein (hs-CRP), fibrinogen, homocysteine, and erythrocyte (red blood cell [RBC]) folate were evaluated in all subjects. Each subject underwent c-IMT and brachial artery FMD percentage (FMD%) measurements using high-resolution vascular ultrasound. RESULTS - Type 1 diabetic children had higher FPG (173.4±7.9 mg/dL vs. 81.40±1.7mg/dL; P < 0.0001), HbA (8.0 ± 0.2% vs. 5.0 ± 0.1%; P < 0.0001), and hs-CRP (1.8 ± 0.3 vs. 0.70 ± 0.2; P = 0.017) than control children without significant differences in BMI, homocysteine, and fibrinogen levels; RBC folate content; and c-IMT between the groups. Children with type 1 diabetes had lower FMD% than control children (7.1 ± 0.8% vs. 9.8 ± 1.1%; P = 0.04), whereas c-IMT did not differ between groups. CONCLUSIONS - Preadolescent children with type 1 diabetes and mean diabetes duration of 4 years displayed evidence of low-intensity vascular inflammation and attenuated FMD measurements. These data suggest that endothelial dysfunction and systemic inflammation, known harbingers of future cardiovascular risk, are present even in preadolescent children. © 2011 by the American Diabetes Association.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79956067716&origin=inward; http://dx.doi.org/10.2337/dc10-2134; http://www.ncbi.nlm.nih.gov/pubmed/21289230; https://diabetesjournals.org/care/article/34/3/681/38769/Impaired-Endothelial-Function-in-Preadolescent; https://dx.doi.org/10.2337/dc10-2134
American Diabetes Association
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