Screening and treatment outcomes in adults and children with type 1 diabetes and asymptomatic celiac disease: The CD-DIET study
Diabetes Care, ISSN: 1935-5548, Vol: 43, Issue: 7, Page: 1553-1556
2020
- 24Citations
- 371Usage
- 103Captures
- 1Mentions
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Metrics Details
- Citations24
- Citation Indexes24
- 24
- CrossRef6
- Usage371
- Downloads366
- Abstract Views5
- Captures103
- Readers103
- 103
- Mentions1
- News Mentions1
- 1
Most Recent News
Celiac disease ‘frequently’ asymptomatic in type 1 diabetes
Celiac disease as a comorbidity of type 1 diabetes is often asymptomatic, and people with both diseases should closely monitor glucose levels during transition to a gluten-free diet, according to a study. “Celiac disease is a disorder triggered by gluten that is frequently unrecognized and asymptomatic, especially in individuals with type 1 diabetes or other autoimmune conditions,” Farid Mahmud, M
Article Description
OBJECTIVE To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD. RESEARCH DESIGN AND METHODS Asymptomatic patients (8–45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA and continuous glucose monitoring over 12 months. RESULTS Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9–8.2%, N 5 1,298] vs. 4.7% [95% CI 3.4–5.9%, N 5 1,089], P 5 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%, P < 0.0001). Fifty-one participants were randomized to a GFD (N 5 27) or GCD (N 5 24). No HbA differences were seen between the groups (10.14%, 1.5 mmol/mol; 95% CI 20.79 to 1.08; P 5 0.76), although greater postprandial glucose increases (4-h 11.5 mmol/L; 95% CI 0.4–2.7; P 5 0.014) emerged with a GFD. CONCLUSIONS CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85086792802&origin=inward; http://dx.doi.org/10.2337/dc19-1944; http://www.ncbi.nlm.nih.gov/pubmed/32345653; https://clinicaltrials.gov/ct2/show/NCT01566110; https://diabetesjournals.org/care/article/43/7/1553/35555/Screening-and-Treatment-Outcomes-in-Adults-and; https://ir.lib.uwo.ca/paedpub/540; https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=1546&context=paedpub; https://dx.doi.org/10.2337/dc19-1944
American Diabetes Association
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