Intramyocellular lipid and insulin resistance: A longitudinal in vivo H-spectroscopic study in Zucker Diabetic Fatty rats
Diabetes, ISSN: 0012-1797, Vol: 52, Issue: 1, Page: 138-144
2003
- 111Citations
- 54Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations111
- Citation Indexes111
- 111
- CrossRef103
- Captures54
- Readers54
- 52
Article Description
Insulin resistance plays an important role in the pathogenesis of human type 2 diabetes. In humans, a negative correlation between insulin sensitivity and intramyocellular lipid (IMCL) content has been shown; thus, IMCL becomes a marker for insulin resistance. Recently, magnetic resonance spectroscopy (MRS) has been established as a dependable method for selective detection and quantification of IMCL in humans. To validate the interrelation between insulin sensitivity and IMCL in an animal model of type 2 diabetes, we established volume selective H-MRS at 7 Tesla to noninvasively assess IMCL in the rat. In male obese Zucker Diabetic Fatty rats and their lean littermates, IMCL levels were determined repeatedly over 4 months, and insulin sensitivity was measured by the euglycemic-hyperinsulinemic clamp method at 6-7 and at 22-24 weeks of age. A distinct relation between IMCL and insulin sensitivity was demonstrated as well as age dependence for both parameters. Rosiglitazone treatment caused a clear reduction of IMCL and hepatic fat despite increased body weight, and a marked improvement of insulin sensitivity. Thus, the insulin sensitizing properties of rosiglitazone were consistent with a redistribution of lipids from nonadipocytic (skeletal muscle, liver) back into fat tissue.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037219256&origin=inward; http://dx.doi.org/10.2337/diabetes.52.1.138; http://www.ncbi.nlm.nih.gov/pubmed/12502504; https://diabetesjournals.org/diabetes/article/52/1/138/13114/Intramyocellular-Lipid-and-Insulin-ResistanceA; https://dx.doi.org/10.2337/diabetes.52.1.138
American Diabetes Association
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