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Intramyocellular lipid and insulin resistance: A longitudinal in vivo H-spectroscopic study in Zucker Diabetic Fatty rats

Diabetes, ISSN: 0012-1797, Vol: 52, Issue: 1, Page: 138-144
2003
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Article Description

Insulin resistance plays an important role in the pathogenesis of human type 2 diabetes. In humans, a negative correlation between insulin sensitivity and intramyocellular lipid (IMCL) content has been shown; thus, IMCL becomes a marker for insulin resistance. Recently, magnetic resonance spectroscopy (MRS) has been established as a dependable method for selective detection and quantification of IMCL in humans. To validate the interrelation between insulin sensitivity and IMCL in an animal model of type 2 diabetes, we established volume selective H-MRS at 7 Tesla to noninvasively assess IMCL in the rat. In male obese Zucker Diabetic Fatty rats and their lean littermates, IMCL levels were determined repeatedly over 4 months, and insulin sensitivity was measured by the euglycemic-hyperinsulinemic clamp method at 6-7 and at 22-24 weeks of age. A distinct relation between IMCL and insulin sensitivity was demonstrated as well as age dependence for both parameters. Rosiglitazone treatment caused a clear reduction of IMCL and hepatic fat despite increased body weight, and a marked improvement of insulin sensitivity. Thus, the insulin sensitizing properties of rosiglitazone were consistent with a redistribution of lipids from nonadipocytic (skeletal muscle, liver) back into fat tissue.

Bibliographic Details

Kuhlmann, Johanna; Neumann-Haefelin, Claudia; Belz, Ulrich; Kalisch, Jürgen; Juretschke, Hans-Paul; Stein, Marion; Kleinschmidt, Elke; Kramer, Werner; Herling, Andreas W

American Diabetes Association

Medicine

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