Underlying diseases and clinicopathologic variables of thrombocytopenic dogs with and without platelet-bound antibodies detected by use of a flow cytometric assay: 83 cases (2004-2006)
Journal of the American Veterinary Medical Association, ISSN: 0003-1488, Vol: 235, Issue: 8, Page: 960-966
2009
- 50Citations
- 90Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations50
- Citation Indexes49
- 49
- CrossRef34
- Clinical Citations1
- PubMed Guidelines1
- Captures90
- Readers90
- 90
Article Description
Objective-To characterize underlying diseases and clinical and clinicopathologic variables of thrombocytopenic dogs with and without platelet-bound antibodies (PBAs) and to evaluate clinicopathologic variables of dogs with primary immune-mediated thrombocytopenia (IMT). Design-Retrospective case series. Animals-83 thrombocytopenic dogs. Procedures-Medical records were reviewed to identify dogs in which PBA tests were performed between 2004 and 2006; PBAs were measured via flow cytometry. Results-PBAs were detected in 37 of 83 (45%) dogs. Thirteen dogs were suspected of having primary IMT. Median platelet counts were significantly lower in dogs with PBAs, compared with counts in dogs without PBAs. Dogs suspected of having primary IMT had significantly lower median platelet counts, compared with counts for those with secondary IMT. Mean platelet volume (MPV) was increased (> 14.3 fL) significantly more often in dogs without PBAs (19/33 (58%]) than in dogs with PBAs (7/26 [27%)). No dogs suspected of having primary IMT had an increase in MPV. Examination of bone marrow aspirates revealed an increase in megakaryopoiesis in a higher percentage of dogs with PBAs (14/21 [67%]) than in dogs without PBAs (7/18 [39%]). An increase in megakaryopoiesis was detected in all dogs suspected of having primary IMT that had a bone marrow analysis. Conclusions and Clinical Relevance-Platelet counts, results of bone marrow analysis, and MPV may be helpful in dogs for the differentiation between primary IMT and thrombocytopenia resulting from other diseases. An MPV within or less than the reference range did not rule out an increase in megakaryopoietic activity.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70350534173&origin=inward; http://dx.doi.org/10.2460/javma.235.8.960; http://www.ncbi.nlm.nih.gov/pubmed/19827982; https://avmajournals.avma.org/view/journals/javma/235/8/javma.235.8.960.xml; https://dx.doi.org/10.2460/javma.235.8.960; https://avmajournals.avma.org/doi/abs/10.2460/javma.235.8.960
American Veterinary Medical Association (AVMA)
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