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Determination of β-blocking receptor drugs in silica gel TLC systems with the mobile phase containing surfactant

Current Issues in Pharmacy and Medical Sciences, ISSN: 2084-980X, Vol: 35, Issue: 4, Page: 212-218
2022
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Recent Findings from Medical University of Lublin Highlight Research in Medical Science (Determination of b-blocking receptor drugs in silica gel TLC systems with the mobile phase containing surfactant)

2023 MAR 22 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Drug Daily -- Current study results on medical science have been published.

Article Description

Eight drugs blocking beta-adrenergic receptors activity (acebutolol, alprenolol, atenolol, oxprenolol, labetalol, metoprolol, propranolol and sotalol) were investigated through the use of the thin-layer technique with its mobile phase containing surfactant. Assessment of the effect of surfactant presence and 1-propanol concentration in the mobile phase on the retention and separation of investigated solutes was then carried out wherein the effect of the surfactant concentration on the zone shape properties (asymmetry and tailing coefficient) was investigated. The method was applied for the quantitative analysis of the chosen solutes, and the LOD and LOQ values of chosen were determined. These were as follows: acebutolol - 1.11 and 3.36 μg/spot, metoprolol 1.45 μg/spot, 4.4 μg/spot. The chosen system is environmentally friendly due to using silica gel plates and only 5% of propanol in water.

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