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Research progress on N-adenosylate methylation RNA modification in heart failure remodeling

Journal of Translational Internal Medicine, ISSN: 2224-4018, Vol: 10, Issue: 4, Page: 340-348
2022
  • 17
    Citations
  • 0
    Usage
  • 2
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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Most Recent News

Investigators at China Medical University Report Findings in Heart Failure (Research Progress On N-6-adenosylate Methylation Rna Modification In Heart Failure Remodeling)

2022 DEC 09 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Cardiovascular Daily -- Investigators publish new report on Heart Disorders and Diseases

Review Description

Cardiovascular disease (CVD) is the major cause of disability-adjusted life years (DALY) and death globally. The most common internal modification of mRNA is N6-adenosylate methylation (m6A). Recently, a growing number of studies have been devoted to researching cardiac remodeling mechanisms, especially m6A RNA methylation, revealing a connection between m6A and cardiovascular diseases. This review summarized the current understanding regarding m6A and elucidated the dynamic modifications of writers, erasers, and readers. Furthermore, we highlighted m6A RNA methylation related to cardiac remodeling and summarized its potential mechanisms. Finally, we discussed the potential of m6A RNA methylation in the treatment of cardiac remodeling.

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