Protein kinase c activity of colonic mucosa in ulcerative colitis
Scandinavian Journal of Gastroenterology, ISSN: 0036-5521, Vol: 27, Issue: 4, Page: 275-280
1992
- 18Citations
- 2Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations18
- Citation Indexes18
- 18
- CrossRef14
- Captures2
- Readers2
Article Description
Protein kinase C (PKC) activity was measured in the inflamed colonic mucosa of 24 patients with ulcerative colitis and in the normal colonic mucosa of 10 patients with other benign diseases. The particulate fraction activity in ulcerative colitis mucosa was significantly increased compared with that of normal mucosa (320 ± 47 versus 200 ± 30 pmol/min/mg protein;p < 0.05). Inflamed ulcerative colitis mucosa also showed significantly increased total PKC activity in the particulate fractions compared with normal mucosa (147 ± 26 versus 37 ± 8 pmol/min/mg tissue;p < 0.05). Mucosal samples from ulcerative colitis patients were divided into 12 with mild and 12 with severe inflammation by histologic examination. The particulate PKC activity of severely inflamed mucosa was significantly lower than that of mildly inflamed mucosa (p < 0.05). These results indicate that colonic inflammation in ulcerative colitis may be associated with altered cellular PKC activity. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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