Changes in the metabolism of labelled acetanilide and binding of isotope to serum and liver macromolecules during chronic administration
Xenobiotica, ISSN: 0049-8254, Vol: 2, Issue: 6, Page: 551-565
1972
- 9Citations
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations9
- Citation Indexes9
- CrossRef8
Article Description
1. The metabolism of H-acetanilide was studied in rats (a) after a single intraperitoneal dose of 200 mg/kg, (b) after 1-5 days of continuous feeding of 0.8% of labelled acetanilide in the diet, and (c) at weekly intervals during 4 weeks of such feeding. The three experimental groups excreted 56, 62 and 86% of dose, respectively, in 24 h samples of urine. 2. 4-Hydroxyacetanilide, the major metabolite, was found free, as well as conjugated with glucuronic and sulphuric acids in all groups. The glucuronide fraction increased from 4.6% (single i.p. dose), and 6.0% (1 day feeding) to 16% of dose at 1 week. The sulphate conjugate of 4-hydroxyacetanilide decreased from 70% of dose at 24 h to only 43% after 1 week of feeding. 3. Blood levels of radioactivity at 1 week were 11-fold higher than after a single dose. The liver contained 15 times more isotope at 4 weeks than after a single dose. Binding to DNA, RNA and proteins of liver at 4 weeks was 180-, 15- and 33-fold greater, respectively, than the values found after a single i.p. dose. © 1972 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Bibliographic Details
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know