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The metabolism of 4-substituted n-ethyl-n-methylanilines: III. Effect of various potential inhibitors, activators and inducers on αc- and n-oxidation

Xenobiotica, ISSN: 0049-8254, Vol: 13, Issue: 9, Page: 521-529
1983
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1. The αC-oxidation of N-ethyl-N-methylaniline and of the 4-chloro and 4-methyl derivatives was inhibited by SKF-525A, DPEA, carbon monoxide and cyanide and induced by phenobarbitone but not by 3-methylcholanthrene pretreatment. 2. The N-oxidation of these tertiary anilines was not influenced by SKF-525A, carbon monoxide or cyanide, nor by phenobarbitone or 3-methylcholanthrene pretreatment. 3. The N-oxidase was activated by DPEA and n-octylamine and inhibited by 1-naphthylthiourea. 4. The evidence indicates that metabolic αC-oxidation of these substrates is mediated by a cytochrome P-450-dependent pathway whilst N-oxidation is mediated by a flavo-protein amine oxidase. © 1983 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Bibliographic Details

J. W. Gorrord; L. H. Patterson

Informa UK Limited

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Environmental Science

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