The metabolism of 4-substituted n-ethyl-n-methylanilines: III. Effect of various potential inhibitors, activators and inducers on αc- and n-oxidation
Xenobiotica, ISSN: 0049-8254, Vol: 13, Issue: 9, Page: 521-529
1983
- 12Citations
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations12
- Citation Indexes12
- 12
- CrossRef10
Article Description
1. The αC-oxidation of N-ethyl-N-methylaniline and of the 4-chloro and 4-methyl derivatives was inhibited by SKF-525A, DPEA, carbon monoxide and cyanide and induced by phenobarbitone but not by 3-methylcholanthrene pretreatment. 2. The N-oxidation of these tertiary anilines was not influenced by SKF-525A, carbon monoxide or cyanide, nor by phenobarbitone or 3-methylcholanthrene pretreatment. 3. The N-oxidase was activated by DPEA and n-octylamine and inhibited by 1-naphthylthiourea. 4. The evidence indicates that metabolic αC-oxidation of these substrates is mediated by a cytochrome P-450-dependent pathway whilst N-oxidation is mediated by a flavo-protein amine oxidase. © 1983 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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