Role of cytochrome b in the oxidative metabolism of polychlorinated biphenyls catalyzed by cytochrome P450
Xenobiotica, ISSN: 0049-8254, Vol: 26, Issue: 4, Page: 405-414
1996
- 5Citations
- 2Captures
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Metrics Details
- Citations5
- Citation Indexes5
- CrossRef2
- Captures2
- Readers2
Article Description
The role of cytochrome b in the cytochrome P450-dependent hydroxylation of tetrachlorobiphenyl (TCB) isomers was examined using a reconstituted system consisting of CYP2B1 and CYP1A1 and rat liver microsomes. By addition of cytochrome b to the reconstituted system containing CYP2B1, the 3-hydroxylation of 2,5,2,'5'- and 2,5,3',4'-TCB was increased about six-fold, but the 3- and 5-hydroxylation of 2,4,3',4'-TCB was decreased by about 50%. All hydroxylations of 3,4,3',4'-, 2,5,3',4'- and 2,4,3',4'-TCBs were decreased by addition of cytochrome b to the reconstituted system containing CYP1A1. In stoichiometry measurements, changes in NADPH oxidation and coupling efficiency by addition of cytochrome b was observed and these differed according to the position of chlorine atoms of TCBs and cytochrome P450 isoforms used in the systems.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029658049&origin=inward; http://dx.doi.org/10.3109/00498259609046719; http://www.ncbi.nlm.nih.gov/pubmed/9173681; http://www.tandfonline.com/doi/full/10.3109/00498259609046719; https://dx.doi.org/10.3109/00498259609046719; https://www.tandfonline.com/doi/abs/10.3109/00498259609046719; http://www.tandfonline.com/doi/abs/10.3109/00498259609046719; http://www.informapharmascience.com/doi/abs/10.3109/00498259609046719; https://www.tandfonline.com/doi/full/10.3109/00498259609046719
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