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Effects of chlorphentermine and nitrogen dioxide on murine alveolar macrophages

Experimental Lung Research, ISSN: 0190-2148, Vol: 14, Issue: 5, Page: 619-636
1988
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Male Swiss-Webster mice were treated daily for 14 days with either 120 mg/kg chlorphentermine (CP) to produce pulmonary lipidosis or an equal volume of water. Animals in each treatment group were then exposed by whole-body inhalation to either air or NO for 48 h. Immediately following exposure, alveolar macrophages (MPs) were collected from each animal by bronchoalveolar lavage. Assays performed on adherent viable MPs showed some changes in metabolic reduction, phagocytosis, and killing activity. 5' -Nucleotidase activity and yeast phagocytosis and killing assays suggested that CP elicited an increase in phagocytosis over control levels. Although the percentage metabolic reduction and microbicidal killing activities following CP were not increased when compared to controls, absolute reduction and killing (percentage values times total MPs) were significantly increased. These increased functions seemed to be highly dependent on the large increase in the total number of MPs induced by CP. It is possible that the large accumulation of MPs in the airways of the lipidotic lung may help protect the alveolar epithelium from N0 by quenching free radicals produced during N0-induced lipid peroxidation. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Bibliographic Details

Susan M. White; Dennis B. Denicola; Alan H. Rebar; Gordon S. Born; Wayne V. Kessler

Informa UK Limited

Biochemistry, Genetics and Molecular Biology; Medicine

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