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Pituitary adenomas producing growth hormone, prolactin, and one or more glycoprotein hormones: A histologic, immunohistochemical, and ultrastructural study of four surgically removed tumors

Ultrastructural Pathology, ISSN: 0191-3123, Vol: 5, Issue: 2-3, Page: 171-183
1983
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Article Description

The morphologic features of four pituitary adenomas, removed from 2 men and 2 women between 31 and 62 years of age, are reported. The tumors contained growth hormone (GH), prolactin (PRL), and one or more glycoprotein hormones-usually thyrotropin (TSH). Three tumors were associated with acromegaly and one with hyperprolactinemia. Hyperthyroidism was not evident in any of the patients. In the tumors of acromegalic subjects, GH-containing cells were the most numerous, whereas PRL cells were dominant in the adenoma accompanied by hyperprolactinemia. Electron microscopy revealed plurimorphous tumors comprised of various proportions of morphologically different cell types: densely granulated GH cells, TSH-like cells, and the less common mammosomatotrophs and PRL cells. It is suggested that pituitary adenomas producing GH, PRL, and glycoprotein hormones derive from the same precursor; their immunocytochemical profile, fine structural appearance, and endocrine function may depend on the degree and direction of the cellular differentiation. © 1983 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Bibliographic Details

Eva Horvath; Kalman Kovacs; Bernd W. Scheithauer; Raymond V. Randall; Edward R. Laws; Michael O. Thorner; George T. Tindall; Daniel L. Barrow

Informa UK Limited

Biochemistry, Genetics and Molecular Biology; Medicine

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